IN HER POST of March 30, 2008, Lori Perkins of L. Perkins Agency suggests that to get a major New York publisher interested, authors need to be able to guarantee at least 25,000 copies of their book will sell.
“…every book has to be perfect (not too long or short and well crafted) and come with [...]

I’ve seen references to this work several times, now, the latest on Janet Reid’s blog.

http://jetreidliterary.blogspot.com/2008/04/anyone-who-tells-you-agents-dont-read.html
FICTION: DEBUT
Scientist, doctor and researcher with over 50 major awards in science and a professor [of] medicine at the Mayo Clinic, Dr. James Levine’s debut RIVER OF WORDS, the surprisingly hopeful story of 15-year old girl whose poverty-stricken family sells her [...]

Well, having thought long and hard on Janet Reid’s post of March 30, 2008, I think my best option is to finish the S.L. novel, and shop it instead of the recently completed T.W. or the nearing completion T.V.S. That said, I probably ought to email the agents with T.W. and pull it from [...]

Janet Reid wrote an excellent, informative post, found here: http://jetreidliterary.blogspot.com/2008/03/when-less-is-not-more.html